DERMATOLOGY : Advanced Research with Porsolt, a Leading Dermatology Contract Research Organization
Porsolt, as a specialized dermatology contract research organization, is committed to offering a comprehensive array of services, capabilities, and technologies for dermatology studies. We provide vital support to scientists and medical researchers, underpinned by our expertise in the development and application of both in vitro and in vivo models. These models are integral to advancing dermatological research and propelling the drug development process.
Our dermatology contract research organization specialized services
A key aspect of our services as a dermatology contract research organization is the provision of dermatology tests, which are fundamental in evaluating potential therapeutics in this field. Utilizing our models for these dermatology tests, we offer researchers a dependable platform for assessing the efficacy, safety, and underlying mechanisms of prospective drug candidates.
Concurrently, our preclinical models enable comprehensive studies on disease progression, therapeutic interventions, and treatment outcome assessments. They unlock valuable insights into the underlying biological mechanisms, facilitating the development of effective treatments.
SCROLL
DERMATOLOGY
INFLAMMATORY PATHWAY AND ANTI-INFLAMMATORY ACTIVITY
| Atopic Dermatitis - Poly (I:C) induced cytokine release | NHEK |
| Cannabinoid anti-inflammatory evaluation Cytokine release | NHEK |
| Cytokine release | Keratinocytes Dendritic cells (Langerhans) |
| IL-6 induced secretion (by IL-17) | NHDF |
| Immune cell activation | Lymphocytes, PBMC Dendritic cells (Langerhans) |
| Immune cell proliferation | Lymphocytes, PBMC |
| Immune cells phagocytosis (E.coli particles) | Macrophages Dendritic cells (Langerhans) |
| TNFα induced cytotoxicity | L929 |
OXIDATIVE DAMAGE AND ANTI-OXIDANT POTENTIAL
| Atopic Dermatitis - Poly (I:C) induced cytokine release | NHEK |
| Cannabinoid anti-inflammatory evaluation Cytokine release | NHEK |
| Cytokine release | Keratinocytes Dendritic cells (Langerhans) |
| IL-6 induced secretion (by IL-17) | NHDF |
| Immune cell activation | Lymphocytes, PBMC Dendritic cells (Langerhans) |
| Immune cell proliferation | Lymphocytes, PBMC |
| Immune cells phagocytosis (E.coli particles) | Macrophages Dendritic cells (Langerhans) |
| TNFα induced cytotoxicity | L929 |
PIGMENTATION
| Endothelin signaling pathway - Calcium | Normal human epidermal melanocyte (NHEM) |
PREDICTIVE TOXICITY
| Cytotoxicity - Cell viability | Cell lines (3T3, L929, HaCaT) NHEK, NHDF |
| Ocular irritation HET-CAM | Chicken egg |
| Skin irritation | Reconstituted human epidermis |
| Skin irritation | Monocyte cell line (THP1) |
PROTECTION AGAINST POLLUTION
| Indoor dust - Inflammatory cytokine release | Dendritic cells (Langerhans) |
| Urban dust - Inflammatory cytokine release | NHEK Dendritic cells (Langerhans) |
| Urban dust - Lipid peroxidation | NHEK |
| Urban dust - Reactive Oxygen Species induction (ROS) | NHEK |
SKIN AGING
| Senescence (oxidative stress induction or high passage senescence) | Keratinocytes |
| Total collagen secretion | Elderly fibroblast donor |
| Wound healing | NHEK |
| Elderly fibroblast or keratinocyte donor | NHEK |
SKIN MICROCIRCULATION
| Angiogenesis | NHDF & HUVEC |
| Calcitonin Gene Related Peptide signaling pathways (CGRP) | HDMEC |
SKIN REGENERATION
| Cell migration/Wound healing | HaCaT, NHEK, NHDF |
| Cell proliferation | HaCaT, NHEK, NHDF |
| Total collagen formation | NHDF |
IN VIVO
| Allergic Contact Dermatitis | Pig |
| Imiquimod-induced psoriasis-like skin inflammation | Mouse |
| Pruritogens-induced scratching behavior | Mouse – Rat |
| Wound healing | Mouse |
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Histology (IHC-P) | Skin structure (keratin10, loricrin, filaggrin, elastin, involucrin, e-cadherin, ZO-1) | Human (explant or RHE) |
| Cell proliferation (Ki67,…) | Human (explant or RHE) | |
| Immune cells (macrophages, T-cells, Langerhans,…) | Human (explant or RHE), Mouse, Rat | |
| Staining (paraffin slices) | Hematoxylin & Eosin, Sirius red, Masson’s trichrome,… | Multiple species & tissues |
| CBA | Inflammation pathway IL-6, IL-10, MCP-1or IL-8 IFN-γ or IL-1β ,TNF and IL-12p70 | Human (cell supernatant) |
| ELISA | Inflammatory cytokine (TNF-α , IL-6, IL-17) | Mouse (ear) |
| CBA - ELISA - WB - IHC-PIHC-Fr - ICC - HTRF | Other targets upon request | Multiple species & biological specimens |
At the heart of our dermatology contract research organization services and capabilities lies dermatology histology and bioanalysis techniques—a critical component of our analytical capabilities. Our team of skilled scientists and technicians harnesses advanced techniques and experience in dermatology.
Porsolt also offers an extensive range of dermatology lab tests services, encompassing a wide array of assays, biomarker analyses, and investigative techniques tailored to meet specific research requirements. These dermatology lab tests provide researchers with invaluable data throughout the entire drug development process.
An experienced team of scientists for your dermatology studies
In our role as a reliable collaborator in dermatology research, our contract research organization is proficient in preclinical dermatology studies. We are committed to providing high-quality research services that contribute to the advancement of scientific technologies and the improvement of patient care in the dermatology field.
Our team, comprising seasoned scientists, researchers, and technicians, works in close cooperation with clients, offering customized solutions designed to address the specific requirements of each project. By leveraging our resources, extensive expertise, and rigorous methodologies, we empower researchers to make significant strides in understanding dermatological diseases and developing effective therapeutic expertise interventions.
Experience the capabilities of our leading dermatology contract research organization committed to driving innovation in skin health research. We are dedicated to equip researchers with the necessary tools and knowledge to tackle the complexities of dermatological studies.
For more information about our dermatology contract research organization services and how we can support your specific research needs, please visit our website or contact us.
