LIVER & HEPATIC SYSTEM : Developing Effective Therapeutic Solutions for Liver Diseases
At Porsolt, we are dedicated to advancing liver research and understanding the complexities of the hepatic system through comprehensive in vivo and in vitro liver models, histology, and bioanalysis services. With extensive experience in preclinical studies, safety and efficacy, we have developed specialized models that focus on the liver, providing invaluable insights into the effects of compounds on hepatic function.
SCROLL
LIVER & HEPATIC SYSTEM
| Acetaminophen (acute model) | Mouse |
| Cholestasis/Bile canaliculi network | Primary hepatocytes sandwich configuration, Rat |
| Glutathione (GSH), intracellular GSH content | Primary human and rat hepatocytes |
| Steatosis/Lipid, intracellular accumulation: neutral lipids | Primary human and rat hepatocytes |
| Cytolysis | Primary human and rat hepatocytes |
| Lipid, intracellular accumulation: phospholipids | Primary human and rat hepatocytes |
| 3D Hepatotoxicity (Viability) | Primary human hepatocyte spheroids |
| Acetaminophen (acute model) | Mouse |
| Bile Duct Ligation (BDL) (chronic model) | Rat |
| Carbon tetrachloride (CCl4) (acute model) | Rat |
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Histology (IHC-P) | Hepatic transporters (MRP-2, ZO-1,…) | Rat (liver) |
| Hepatocellular ballooning (H&E, p62) | Rat (liver) | |
| Staining (paraffin slices) | Hematoxylin & Eosin, Sirius red, Masson’s trichrome,… | Multiple species & tissues |
| Biochemical | Lipid panel (HDL, LDL, FFA, TG, cholesterol…) | Mouse, Rat (plasma, serum) |
| Liver function panel (ALAT, ASAT, ALP, bilirubin…) | Mouse, Rat (plasma, serum) | |
| ELISA | Inflammatory cytokines (TNF-α /IL-1β /IL-6) | Mouse, Rat (plasma, serum) |
| CBA - ELISA - WB - IHC-PIHC-Fr - ICC - HTRF | Other targets upon request | Multiple species & biological specimens |
| Signaling Pathways (IF in vitro) | Nrf2 pathway (Nrf2, HO-1 and NQO1) | Mouse, Human, Rat |
| ATP-binding cassette (ABC) transporters (MRP-2) | Mouse, Human, Rat |
Advanced Liver Research
Porsolt is committed to advancing research in hepatic science and deepening the understanding of the liver and hepatic system. Leveraging our extensive experience in preclinical safety and efficacy studies, we have developed specialized models centered on the liver. These models provide significant insights into the impact of compounds on hepatic function.
Preclinical liver studies play a pivotal role in advancing our understanding of the hepatic system and its functions. We can also analyze tissue samples at a microscopic level, allowing us to observe structural changes, assess cellular health, and detect any abnormalities that could indicate potential liver disorders or the impact of therapeutic interventions. Our state-of-the-art in vivo liver models, histology labs, and bioanalysis capabilities provide researchers and pharmaceutical companies with the necessary tools to make informed decisions during drug development, ensuring the safety and efficacy of potential treatments.
Our variety of Hepatic health services
Our team of experts use preclinical liver imaging as well to visualize the effects of compounds on the liver in real time. This technology allows us to see how compounds are absorbed, distributed, and metabolized in the liver, and it can help us to identify any potential liver toxicity.
Our CRO services also include liver fibrosis models to study the progression of liver fibrosis, chronic liver disease, leading to cirrhosis and liver failure, allowing for testing new therapies. This, combined with the ability to measure the levels of liver enzymes and other biomarkers, can assist with detecting liver damage. Finally, we use liver histology techniques to visualize the microscopic structure of it and to identify any changes that may be caused by compounds. This technique allows us to see how compounds are affecting the liver at a cellular level, and it can help us to identify any potential liver toxicity.
Porsolt is committed to advancing the understanding of liver health. We offer a comprehensive suite of services and liver models to help you better understand the effects of compounds on the liver and hepatic system.
