OBESITY & METABOLIC DISORDERS DISEASE : Healthier Futures with our services and capabilities as a Preclinical CRO for Obesity and Metabolic Disorders
At Porsolt, your preclinical CRO for obesity and metabolic disorders, and pain, we specialize in providing comprehensive services for preclinical studies of obesity and metabolic disorders. We offer invaluable support to scientists and medical researchers, with our core expertise lying in the development and utilization of in vitro and in vivo models. We believe that our expertise in preclinical studies for obesity can help you achieve your research goals and bring new therapies to the light.
Our Preclinical CRO services and capabilities for Obesity and Metabolic Disorders
At Porsolt, we contribute to unraveling this complex relationship through our comprehensive range of preclinical studies and models. Our focus on obesity and metabolic diseases extends beyond their physical manifestation, delving into the molecular and cellular levels, including the intricate histology and bioanalysis of metabolic tissues. We offer carefully crafted animal models of obesity and metabolic disorders, including obese mouse models, to simulate and study the physiological changes and underlying mechanisms.
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OBESITY & METABOLIC DISORDERS DISEASE
Diabetes
Diabetes is a chronic disease that affects how the body turns food into energy. Our Preclinical CRO for Obesity and Metabolic Disorders use models of diabetes to study the effects of potential new therapies.
| Glucose stimulated insulin secretion | Rat insulinoma INS-1 cells |
| Chemically-induced animal models Alloxan-induced type 1diabetes single injection of alloxan |
Rat |
| HFD/STZ-induced Type 2 diabetes high fat diet and single injection of streptozotocin | Rat |
| Streptozotocin (STZ)-induced type 1 diabetes single injection of streptozotocin | Mouse - Rat |
| Genetic Animal Models Zucker Diabetic Fatty (ZDF) type 2 diabetes, glucose intolerance, hyperinsulinemia… |
Rat |
| Nutritional Animal Models Diet-induced obesity (DIO) special diets |
Mouse |
| Assessments Insulin tolerance test (ITT) |
Mouse – Rat |
| Intravenous glucose tolerance test (IVGTT) | Rat |
| Oral glucose tolerance test (OGTT) HOMA-IR, QUICKI and ISI calculation | Mouse – Rat |
Metabolic Disorders
Metabolic disorders are a group of diseases that affect how the body uses food for energy. Our Preclinical CRO services for Obesity and Metabolic Disorders use in vivo and in vitro preclinical models as well as obesity histology and bioanalysis to study the effects of potential new therapies for these disorders.
| Insulin tolerance test (ITT) | Mouse – Rat |
| Intravenous glucose tolerance test (IVGTT) | Rat |
| Oral glucose tolerance test (OGTT) | Mouse – Rat |
Obesity
Obesity is a complex disorder characterized by excessive body fat. It is caused by a combination of factors, including genetics, environment, and food consumption. Our Preclinical CRO for Obesity use various models of obesity such as obese mouse models, to study the effects of potential new therapies for human obesity.
| Genetic Animal models Leptin-deficience ob/ob - db/db obesity, type 2 diabetes |
Mouse |
| Zucker Fatty obesity, hyperlipidemia… | Rat |
| Nutritional Animal Models Diet-induced obesity (DIO) special diets |
Mouse |
| Assessments Acute 24-hr feeding |
Rat |
| Fast-induced feeding (over 4 hours) | Mouse |
| Food/water intake and body weight gain (3-hr schedule-fed over10 days) | Rat |
| Food/water intake and body weight gain (over 28 days in pathologic animals) | Mouse - Rat |
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| ELISA | Pancreas activity (Insulin, glucagon) | Mouse, Rat (plasma) |
| Adipocytes (Adiponectin, leptin) | Mouse, Rat (plasma) | |
| Sexual hormone (testosteron) | Mouse, Rat (plasma, serum) | |
| GI hormones (Acyl ghrelin) | Mouse, Rat (plasma, serum) | |
| Biochemical | Lipid panel (HDL, LDL, FFA, TG, cholesterol…) | Mouse, Rat (plasma) |
| Liver function panel (ALAT, ASAT, ALP, bilirubin…) | Mouse, Rat (plasma) | |
| Renal function (creatinin, urea, electrolytes…) | Mouse, Rat (plasma, urine) | |
| Diabetes (HbA1c) | Rat (plasma) | |
| Pancreas activity (amylase, lipase) | Mouse, Rat (plasma, serum) | |
| CBA - ELISA - WB - IHC- PIHC - Fr - ICC - HTRF | Other targets upon request | Multiple species & biological specimens |
Porsolt facilitates a deeper exploration of the mechanisms underpinning human obesity and metabolic disorders through meticulously designed animal models, capabilities, and technologies. These models and capabilities are characterized by their ability to replicate key aspects of human metabolic pathways, rendering them invaluable tools for investigating the intricate interplay of genetic predisposition and environmental triggers in the development of human obesity and metabolic disorders. Porsolt’s models of obesity and metabolic diseases , meticulously constructed to mirror human conditions, serve as a bridge between basic science and therapeutic innovation.
Our Commitment to Excellence for each of your Preclinical Studies
Our team of experienced scientists and researchers collaborates closely with our esteemed clients, crafting tailored solutions that address the nuances of each project.
We are dedicated to fostering an environment where researchers can investigate the complexities of preclinical studies for obesity and metabolic disorders with confidence. Our collaborative approach using rigorous methodologies, and a shared commitment to progress, help advance scientific developments toward new horizons in the field.
For more information about our Preclinical CRO for Obesity and Metabolic Disorder services and how we can support your specific research needs, please visit our website or contact us.
