PAIN : Trusted Pain CRO Partner for Advanced Preclinical Studies
As a recognized expert in pain models and capabilities, we offer a diverse range of acute and chronic pain models and inflammation models tailored to the industry’s needs. Our commitment to excellence and extensive expertise make us the ideal Pain CRO for advancing pain research and drug development.
Our Pain CRO‘s focus lies in providing reliable and robust preclinical models of pain, enabling researchers to explore pain mechanisms and evaluate potential therapeutics. Our preclinical animal models for pain encompass a wide variety of approaches, reflecting the complexity and heterogeneity of pain conditions. From acute, and surgical models of pain to chronic pain models and inflammatory pain models, our carefully designed models align with industry requirements, facilitating efficient pain-related studies.
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PAIN DISEASE
Acute Pain
A transient nociceptive pain arising from specific stimuli. Our Pain CRO capabilities, investigate acute pain models, contributing to trials for pain management advancements.
| Cold-induced hyperalgesia | Mouse - Rat |
| Hot Plate | Mouse - Rat |
| Modified Hot Plate | Mouse |
| Pain after local administration | Mouse - Rat |
| Pinchmeter | Mouse - Rat |
| Tail Flick | Mouse - Rat |
Inflammatory
Pain
Inflammatory pain is characterized by heightened sensitivity due to tissue damage and inflammation. Porsolt, a Pain Model CRO specialist, investigates inflammatory pain models to advance pain research and therapeutic development.
| Capsaicin paw | Mouse - Rat |
| Carrageenan-induced acute inflammatory pain (reversal & prevention protocol) | Rat |
| Complete Freund Adjuvant (CFA) - induced acute inflammatory pain | Mouse - Rat |
| Complete Freund Adjuvant (CFA) - induced chronic inflammatory pain: monoarthritis model | Rat |
| Formalin paw (early phase) | Mouse - Rat |
| Formalin paw (late phase) | Mouse - Rat |
| Migraine model | Mouse - Rat |
| Mono-iodoacetate (MIA) - induced chronic inflammatory pain: osteoarthritis model | Rat |
| Mono-iodoacetate (MIA) - induced lower back pain | Rat |
Neuropathic
Pain
Neuropathic pain arises from somatosensory nervous system damage or disease, leading to abnormal pain responses to non-painful stimuli. Porsolt, an expert Pain CRO, explores neuropathic pain models, advancing research for effective pain management.
| Chemotherapy - induced periphera neuropathy (neurite outgrowth) | Peri.4U® neurons (Human) |
| Chemotherapy - induced neuropathic pain: Cisplatin | Rat |
| Chemotherapy - induced neuropathic pain: Vincristine model | Rat |
| Chronic Constrictive Injury - induced neuropathic pain: CCI/Bennett model | Mouse - Rat |
| Diabetic - induced neuropathy | Rat |
| Spinal Nerve Ligation - induced neuropathic pain: SNL/Chung model | Mouse - Rat |
Post-operative
pain
Post-operative pain refers to increased discomfort experienced after a surgical procedure. Our pain CRO, explores post-operative pain with preclinical models of pain syndromes, advancing the understanding of this critical aspect of patient care.
| Brennan model post-operative pain | Rat – Guinea-pig |
Visceral
pain
Visceral pain, experienced in the pelvis, abdomen, chest, or intestines, arises due to insult, damage, or injury to internal organs or tissues. Our Pain CRO expertise, delve into visceral pain research, advancing knowledge and therapeutic solutions for this complex and critical aspect of pain management studies.
| Acetic acid writhing | Mouse |
| Bezold-Jarish reflex (capsaicin) (anesthetized animal) | Rat |
| Colorectal distension (CRD) after 2,4,6 -trinitrobenzenesulfonicacid (TNBS) sensitization | Rat |
| Colorectal distension (CRD) after acetic acid sensitization | Rat |
| Dextran Sodium Sulfate (DSS) - induced colitis | Mouse |
| Parabenzoquinone writhing | Mouse |
Increasing the quality of pain research with our Pain CRO expertise
Our Pain CRO’s team of experts collaborates closely with clients to deliver personalized solutions for their pain research needs. Whether it’s assessing analgesic efficacy, exploring pain-associated symptoms, or investigating the mechanisms underlying pain disorders.
Porsolt’s pain models and capabilities extend beyond mere drug evaluation; we also enable researchers to explore the underlying biology of pain disorders. By utilizing our models of pain and inflammation models, researchers can gain a deeper understanding of pain pathophysiology, leading to novel therapeutic targets and treatment strategies.
Our Pain model CRO services cater to pharmaceutical companies, biotechs, and research institutions, supporting pain research efforts worldwide.
Choosing Porsolt as your Pain CRO partner unlocks a wealth of benefits, including access to our experience in pain research, reliable preclinical models, and a dedicated team of scientific experts.
