RESPIRATORY SYSTEM : Exploring Respiratory Indications with Expert Respiratory CRO Services
The intricate responses of the respiratory system to various compounds and therapies are at the heart of medical advancement. Porsolt, a leading respiratory CRO, offers a comprehensive range of models, and capabilities to scrutinize these effects. With a wealth of experience and a dedication to scientific excellence, we provide researchers with invaluable tools to assess compound efficacy and safety, ultimately contributing to the improvement of respiratory health worldwide.
Our Expertise in Respiratory CRO Services
Porsolt’s expertise shines through with our tailored respiratory preclinical CRO services. We understand that the complexities of the respiratory system demand a multifaceted approach. Leveraging diverse models and species, we meticulously examine airway function, asthma, cough, fibrosis, bronchospasm, and more. Our deep-rooted understanding of these models enables us to conduct comprehensive assessments, delivering accurate insights into the effects of compounds.
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RESPIRATORY SYSTEM
| Isolated pulmonary artery | Rat |
| Isolated trachea | Rat – Guinea-pig |
| Airway function (whole body plethysmography) | Mouse – Rat - Guinea-pig |
| Airway function in large animals | Dogs |
| Airway function under hypercapnia (whole body plethysmography) | Rat |
| Bleomycin-induced pulmonary fibrosis | Mouse |
| Citric acid-induced cough | Guinea-pig |
| Histamine bronchospasm | Guinea-pig |
| LPS-induced pulmonary injury | Mouse |
| Ovalbumin-induced asthma | Guinea-pig |
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Staining (paraffin slices) | Hepatic transporters (MRP-2, ZO-1,…) | Multiple species & tissues |
| CBA | TNF, IL-6, IL-1β , IL-10 and MCP-1 | Mouse (BAL) |
| Biochemical | MPO activity | Mouse (whole lung) |
| Hematology | WBC (White Blood Cell count): Neutrophils, Macrophages, Lymphocytes, Eosinophils,Basophils | Mouse (BAL) |
| ELISA | TNF, IL-6, IL-1β | Mouse (BAL) |
| CBA–ELISA–WB–IHC-PIHC-Fr–ICC–HTRF | Other targets upon request | Multiple species & biological specimens |
Central to unraveling the intricacies of the respiratory system is also our respiratory CRO expertise, capabilities, and technologies, in histology and bioanalysis. Our skilled team employs advanced histological and bioanalytical techniques to analyze tissue samples, unveiling microscopic and biochemical details that shed light on physiological responses. This meticulous approach allows us to identify cellular changes, tissue structure alterations, and disease markers, contributing to a profound understanding of respiratory health for patients.
A Collaborative Approach to Respiratory Research
At Porsolt, collaboration is paramount. Our respiratory CRO services can count on prestigious researchers to design studies tailored to their specific needs. Our team of dedicated scientists, researchers, and technicians works closely with clients to ensure that the chosen models and assessments align with the research objectives.
In our state-of-the-art respiratory system lab, cutting-edge technologies intersect with scientific curiosity. Equipped with the latest tools and methodologies, we delve into the intricacies of the respiratory diseases (asthma, pulmonary disease, cystic fibrosis, chronic sinusitis, etc.), providing robust data that drives progress.
Our experienced team of scientists has a deep understanding of the respiratory system and its complex interactions with other systems in the body. We offer a comprehensive range of respiratory preclinical CRO services, including : preclinical studies, histology of respiratory system as well as a state-of-the-art respiratory system lab.
As the landscape of respiratory health continues to evolve, Porsolt remains dedicated to shaping its trajectory. Through collaborative innovation, meticulous histological and bioanalysis assessments in our advanced histology laboratory, and an unwavering commitment to scientific excellence, we invite you to join us in exploring the frontiers of respiratory studies.
For more information about our Respiratory CRO services and how we can support your specific projects needs, please visit our website and contact us.
