UROGENITAL SYSTEM
Porsolt offers a range of models that address complications specific to, or are associated with, the urogenital system, including the assessment of renal function, bladder function and the genital system.
SCROLL
UROGENITAL SYSTEM
Bladder Function
Bladder function assessment includes a combination of tests that are used to examine the urinary system and how it is working.
EX-VIVO MODELS
| Isolated bladder strip | Rat |
Genital System
Genital system models evaluate potential effects of substances on the genital system.
IN VIVO MODELS
| Isolated uterus | Rat |
| Isolated vas deferens | Guinea-pig |
| Penile erection | Rat |
In Vitro Nephrology
In vitro nephrology can be studied in cellular models from multiple species.
IN VITRO MODELS
| Calcium signaling | Multiple cellular models |
| Cytolysis | Multiple cellular models |
| Lysosomal activity | Multiple cellular models |
| Mitochondrial membrane potential | Multiple cellular models |
Renal Function
A renal function models evaluate kidney function in different conditions.
IN VIVO MODELS
| Diuresis and urinary electrolytes | Mouse – Rat |
| Unilateral ureteral obstruction-induced fibrosis mode | Rat |
HYPERTENSION MODELS
| 5/6 nephrectomy | Rat |
| Chronic (2K1C) Goldblatt hypertension (high renin model) | Rat |
| Chronic DOCA – salt hypertension (low renin model) | Rat |
BIOMARKER ASSAYS
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Histology (IHC-P) | Urothelium structure & thickness (E-Cadherin) | Rat |
| Staining (paraffin slices) | Hematoxylin & Eosin, Sirius red, Masson’s trichrome,… | Multiple species & tissues |
| Biochemical | Renal function (creatinin,urea, electrolytes, total protein, albumin) | Mouse, Rat (urine, serum, plasma) |
| Glomerular filtration (creatinin clearance) | Mouse, Rat (serum, plasma) | |
| Blood Urea Nitrogen (BUN) | Mouse, Rat (urine, serum, plasma) | |
| CBA - ELISA - WB - IHC-PIHC-Fr - ICC - HTRF | Other targets upon request | Multiple species & biological specimens |
